Assessing and predicting chemical toxicity in aquatic toxicology
We explore how exposure to aquatic contaminants impacts development and health of fish and amphibians, with particular focus on endocrine and immune toxicology. Various projects address current challenges in aquatic toxicology such as exposure during critical windows of development, effects of multiple stressors, and extrapolating effects across species. We often use genomic approaches to determine changes in molecular pathways that precede apical effects. This provides information on mechanism of action and identifies early indicators of exposure and potential effects that can be used to screen chemicals for toxicity.
Compounds of interest include polycyclic aromatic hydrocarbons, endocrine-active compounds, pesticides and environmental mixtures such as wastewater effluents. |